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COPY OF PAPERS 
ORIGINALLY FILED 



F ORM P 7 0-1449 , P .HJ& DEPAR T MEN T Oh COMMbKCb 

n^Jl'ATrklT Akin TOAHCUADI/ riCCITC 



LATENT AND TRADEMARK OFFICE 

INFORMATION DISCLOSURE STATEMENT 
FOR PATENT 

(Use several sheets if necessary) 



"ATTY 



#L 0 2 20U^ 

. DOCKb l NO.: | SERIAL NO.: 



Sheet 3of 5 



DX0882XK 



APPLICANT: 



09/898,751 



FILING DATE: 
July 02, 2001 



Wei Wang, ef at 

GROUP: 



1647 



OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 



BD 



BE 



M. Marra, et a/., GenBank, Accession Number AA023970, January 21 , 1997. 
Definition: "mh95f08.M Soares mouse placenta 4NbMP13.5 14.5 Mus musculus cDNA clone 
IMAGE:458727 5* similar to SW:GPR2_HUMAN P46092 PROBABLE G PROTEIN-COUPLED 
RECEPTOR GPR2. [1] ;, mRNA sequence." 



Kouji Matsushima & Joost J. Oppenheim, Cytokine 1 :2-13 ( November 1989. 

"INTERLEUKIN 8 AND MCAF: NOVEL INFLAMMATORY CYTOKINES INDUCIBLE BY IL 1 AND TNF" 



BF 



Catherine J. McMahan, et a/., EMBO Journal, 10(10):2821-2832, 1991 . "A novel IL— 1 receptor, 
cloned from B cells by mammalian expression, is expressed in many cell types" 



BG 



Michael D. Miller, et a/., Proc. Natl. Acad. Sci., USA 89:2950-2954, 1992. 
"The human cytokine I-309 is a monocyte chemoattractant" 



BH 



Janine Morales, et a/., Proc. Natl. Acad. Sci., USA , 96{25):14470-14475, December 7, 1999. 
"CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory t cells" 



Bl 



BJ 



Joost J. Oppenheim, et at., Ann. Rev. Immunol. 9:617-648, 1991 . 
"PROPERTIES OF THE NOVEL PROINFLAMMATORY SUPERGENE 'INTERCRINE' CYTOKINE FAMILY" 

Paul Proost, et ai, J. Leukoc. Biol. 59:67-74, January 1996. 

"Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with 
MCP-r 



BK 



Carol J. Raport, era/., J. Leukoc. Biol. 59:18-23, January 1996. 
"New members of the chemokine receptor gene family" 



BL 



Devora L. Rossi, et ai, J. Immunology , 158(3):1 033-1 036, February 1997. "Identification Through 
Bioinformatics of Two New Macrophage Proinflamitory Human Chemokines MIP-3cc, MIP-3p 1 - 2 " 



BM 



Michel Samson, et aA, Biochemistry 35:3362-3367, 1996. 

"Molecular Cloning and Functional Expression of a New Human CC-Chemokine Receptor Gene" 



BN 



Roger A. Sayle and E. James Milner-White, TIBS , 20:374-376, September 1995. 
1 RASMOL: biomolecular graphics for all" 



Thomas J. Schall, in The Cytokine Handbook , 2nd ed., Academic Press Ltd., NY, pp 419-460, 
1994. "The Chemokines" 



BT 



BO" 



Thomas J. Schall, ef a/., Curr. Opin. Immunol. 6:865-873, 1994. 
"Chemokines, leukocyte trafficking, and inflammation" 



Thomas J. Schall, Cytokine 3:165-183, May 1991. 
"BIOLOGY OF THE RANTES/SIS CYTOKINE FAMILY" 



Br 



EXAMINER 




Thomas J. Schall, ef a/., in The Chemokines , Plenum Press, NY, pp 29-37, 1993. 
"RECEPTOR/LIGAND INTERACTIONS I N THE C-C CHEMOKINE FAMILY- 
DATE CONSIDERED 



*EXAM I NEHf Initial n 
through citation if not (n 
applicant. 



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1/ /^UZ'/O^L 

nether or not citation is in conformance with MPEP 609; Draw line 
conformance and not considered. Include copy of this form with next communication to 




COPY OF PAPERt 
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'ARTMENT OF COMMERCE 
IT AND TRADEMARK OFFICE 

NFORMATION DISCLOSURE STATEMENT 
FOR PATENT 

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1 ■LOfcfVbt) 

JU 2 2002 
TECH CENTER 1 



Sheet 2of 5 



ATTY. DOCKET NO":' 
DX0882XK 



FORMPIO-144y 



APPLICANT: 



WJ2 
09/898,751 



Wei Wang, ef a/. 



FILING DATE: 

July 02, 2001 



GROUP: 



1647 



OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 



AP 



Bernhard Homey, et a/. t Journal of Immunology , 164:3465-3470, April 1, 2000. 

"Cutting Edge The Orphan Chemokine Receptor G Protein-Coupled Receptor-2 (GPR-2, 

CCR10) Binds the Skin-Associated Chemokine CCL27 (CTACK/ALP/ILC)" 



AQ 



R. Horuk, ef a/., J. Leukoc. Biol. 59:29-38, January 1996. 

"The Duffy antigen receptor for chemokines: structural analysis and expression in the brain" 



AR 



Richard Horuk, TIPS 15:159-165, May 1994. 
family' 



"Molecular properties of the chemokine receptor 



AS 



Richard Horuk, Immunol. Today 15:169-174, 1994. 
"The interleukin-8-receptor family: from chemokines to malaria" 



AT 



Toshio Imai, et a/., J. Biol. Chem. , 272(23): 15036-1 5042. 1997. "The T Cell- 
directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 
4" 



AU 



Izuni Ishikawa-Mochizuki, et a/., FEBS Letters , 460(3):544-548, November 5, 1999. 
Molecular cloning of a novel CC chemokine, interleukin-1 1 receptor a-locus chemokine (ILC), 
which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by 
molluscum contagiosum virus" 



AV 



David J. Kelvin, ef a/., J. Leukoc. Biol. 54:604-612, December 1993. 
"Chemokines and serpentines: the molecular biology of chemokine receptors' 1 



AW 



Fang Liao, era/., Biochem. Biophys. Res. Commun. , 236:212-217, 1997. 
"STRL22 Is a Receptor for the CC Chemokine MIP-3a" 



AX 



Fang Liao, era/., J. Immunology , 162:186-194, 1999. "CC-Chemokine Receptor 6 Is Expressed 
on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage 
Inflammatory Protein-3a" 



AY 



Patricia J. Lodi, ef a/., Science 263:1762-1767, March 25, 1994. "High-Resolution Structure of the 
P Chemokine hMIP-1p by Multidimensional NMR" 



AZ 



Adriano Marchese, era/., Genomics , 23(3):609-618, 1994. 

"Cloning of Human Genes Encoding Novel G Protein-Coupled Receptors" 



BA 



A. Marchese, ef aA. GenBank , Accession Number U13667, L35537, April 1, 1995. 
Definition : "Human G protein-coupled receptor (GPR2) gene, partial cds." 



BB 



M. Marra, et ai, GenBank , Accession Number AA930619, April 23, 1998. 
Definition: "vy67b03.r1 Stratagene mouse macrophage (#937306) Mus musculus cDNA clone 
IMAGE: 131 1245 5' similar to SW:GPR2_HUMAN P46092 PROBABLE G PROTEIN-COUPLED 
RECEPTOR GPR2.; mRNA sequence." 



BC 



EXAMINER 



M. Marra, ef a/., GenBank , Accession Number AA87 1520, March 16, 1998. 
Definition. M vq36e07.r1 Barstead bowel MPLRB9 Mus musculus cDNA clone IMAGE: 1096356 5' 
similar to SW:GPR2_HUMAN P46092 PROBABLE G PROTEIN-RECEPTOR GPR2. ;, mRNA 
sequence." 



•EXAMINER: 

through citation 
applicant. 



ILK: Initia^rnreTe 
station if npj/in co 



DATE CONSIDERED 

, \ I !//>2iVQc^ 

eTence Considered, whether or not citation is in conformance with MPEP 609; Draw line 
conformance and not considered. Include copy of this form with next communication to 




0 0 2 2002 



TECH 



ATTY. DOCKET NO.: 
DX0882XK 



CENTER 

NO.: II 



1600/2900 



Sheet 1 of 5 



SERIAL NO.: 

09/898,751 



FORMPTO-144 1 



INFORMA 



DEPARTMENT OF COMMERCE 
TENT AND TRADEMARK OFFICE 

ISCLOSURE STATEMENT 
FOR PATENT 



(Use several sheets if necessary) 



APPLICANT : 



Wei, Wang, et al 



FILING DATE: 
July 02, 2001 



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1647 



U.S. PATENT DOCUMENTS 



CLASS 



[FILING DATE IF 
APPROPRIATE 



'EXAMINLR 
INITIAL 



DOCUMENT 
NUMBER 



"DATE" 



NAME 



SUB- 
CLASS 



AA 



5,665,345 



9/9/97 



Yarchoan et al. 



FOREIGN PATENT DOCUMENTS 



CLASS 



SUB- 
CLASS 



TRANSLATION 



DOCUMENT 
NUMBER 



"DATE" 



COUNTRY 



YES" 



AB 



WO 98/23750 



6/4/98 



PCT 



OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 



AC 



Sunil K. Ahuja, et al., Immunol. Today 15:281-287, 1994. "Chemokine receptors and molecular 
mimicry" 



AD 



Ghalig Alkatib, et al., Science 272:1955-1958, June 28, 1996. 

"CC CKR5: A RANTES, MIP-1a, MIP-10 Receptor as a Fusion Cofactor for Macorphage-Tropic 

mv-r 



AE 



Masataka Baba, et al., J. Biological Chemistry , 272{23):14893-14898, June 6, 1997. "Identification 
of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC" 



Kevin B. Bacon, et al., Int. Arch. Allergy Immunol. 109:97-109, 1996. 
"Chemokines as Mediators of Allergic Inflammation" 



AF 



AG 



Michael Baiter, Science 272:1740, June 21, 1996. "A Second Coreceptor for HIV in Early Stages 
of Infection" 



AH 



Ian Clark-Lewis, et al, J. Leukoc. Biol. 57:703-711, 1995. 
'Structure-activity relationships of chemokines" 



Al 



HongKui Deng, etal., Nature 381:661-666, June 20, 1996. "Identification of a major co-receptor 
for primary isolates of HIV-1" 



AJ 



Tatjana Dragic, ef al., Nature 381 :667-673, June 20, 1996. "HIV entry into CD4+ cells is mediated 
by the chemokine receptor CC-CKR-5" 



AK 



Tobias Doerks, etal., TIG, 14(6):248-250, June 1998. 
'Protein annotation: detective work for funtion prediction" 



AL 



David P. Gearing, ef a/., Embo Journal , 8(12):3667-3676, 1989. "Expression cloning of a receptor 
for human granulocyte-macrophage colony-stimulating factor" 



AM 



David R Greaves, et al., J. Exp. Med. , 186(6):837-844, September 15, 1997. 
"CCR6, a CC Chemokine Receptor that Interacts with Macrophage Iflammatory Protein 3a and Is 
Highly Expressed in Human Dendritic Cells" 



AN 



Angela M. Gronenborn, etal., Prot. Engg. 4:263-269, 1991. 

"Modeling the three-dimensional structure of the monocyte chemo-attractant and activating 
protein MCAF/MCP-1 on the basis of the solution structure of interleukin-8" 



AO 



EXAMINE 



Kunio Hieshima, et al., J. Biotogical Chemistry , 272(9):5846-5853, February 28,1997. 
"Molecular Cloning of a Novel Human CC Chemokine Liver and Activation-regulated Chemokine 

(LARC) Expressed in Liver" 

DATE CONSIDfcRbU 



JJ 



finance with 



'EXAMINER: I nitiaHf reference considered, whether or not citation is in conformance 1 with MPEP 609; Draw line 
through citation if nol/in conformance and not considered. Include copy of this form with next communication to 
applicant. _ — 



COeY OF PAPERS 
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F-OKMP I O-144U \^ U.5J5EPARTMENT OF COMMERCE 

N& (f> P^ENT AND TRADEMARK OFFICE 

INFORMATIO^f©SgClOSURE STATEMENT 
FOR PATENT 

(Use several sheets if necessary) 



"ATTY 



. DOCKET NO.: 
DX0882XK 



SERIAL NO.: 

09/898,751 



APPLICANT: 



Wei Wang, et al 



FILING DATE: 

July 02, 2001 



GROUP: 



1647 



OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 



Stephen J. O'Brien and Michael Dean Scientific American , 277:44-52, September 
In Search of AIDS-Resistance Genes" 



Bahram Bodaohi et al.. J. Exp. Med. , 188 (5): 8S5-866, September 1998. 

"Chemokine Sequestration by Viral Chemoreceptors as a Novel Escape Strategy: Withdrawl of 

Chemokines from the Environment of Cytornegaloryir^ Cells" 

Adriano Marchese. et al. Genomics. , 23:609-618, July 1994. 

"Cloning of Human Genes Encoding Novel G Protein-Coupled Receptors" 



EXAMINER 




'EXAXfl 
through citatio 
applicant. 



DATE CONSIDfcRLO 



lal if reference~considered, whether or not citation is in conformancewith MPEP 609; Draw line 
not in conformance and not considered. Include copy of this form with next communication to 



COKY OF PAPERS 
ORIGINALLY FILED 



JUL 0 2 200? 
TECH CENTER 150029CC. 




COPY OF PAPERS 
ORIGINALLY FILED 



FORM PI 0-1449 



DEPARTMENT OF COMMERCE 

Stent and trademark office 
INFORMATION DISCLOSURE STATEMENT 
FOR PATENT 

(Use several sheets if necessary) 



M 0 2 2002 



"ATTY 

DX0882XK 

APPLICANT: 



Sheet 4of 5 



09/898,751 



Wei Wang, etal 



FILING DATE: 

July 02, 2001 



GROUP: 



1647 



OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 



4& 



BF 



Mark Y. Stoeckle, et al., The New Biologist 2:313-323, April 1990. 

TWO BURGEONING FAMILIES OF PLATELET FACTOR 4-RELATED PROTEINS: MEDIATORS OF THE 
INFLAMMATORY RESPONSE" 



BT 



Robert M. Strieter, et al., J. Inv. Med. 42:640-651, December 1994. "Acute Lung Injury: The Role 
of Cytokines in the Elicitation of Neutrophils" 



BIT 



Robert M. Strieter, et al,, J. Leukoc. Biol. 57:752-762, May 1995. "Role of C-X-C chemokines as 
regulators of angiogenesis in lung cancer" 



b\t 



Angus W. Thompson, Ed., The Cytokine Handbook , 2nd ed., The Academic Press Inc.: San 
Diego, CA, 1994. 



Alain P. Vicari, etal., J. Allergy Clin. Immun. , 99(1) part 2:S246, Abstract 1003, January 1997. 
TECK: a novel CC Chemokine associated with T-cell development" 



BW 



B5C 



Alain P. Vicari, etaL, Immunity , 7:291-301, August 1997. 

TECK: a Novel CC Chemokine Specifically Expressed by Thymic Dendritic Cells and Potentially 
Involved in T Cell Development" 



BT 



Ulrich O. Wenzel and Hanna E. Abboud, Am. J. Kidney Diseases 26:982-994, December 1995. 
'Chemokines and Renal Disease" 



Ryu Yoshida, et al„ J. Biological Chemistry , 272(21 ):1 3803-1 3809, May 23, 1997. 
"Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific 
Functional Ligand for EBI1, CCR7" 



BT 



Osamu Yoshie, et al.. J. Leukocyte Biology , 62(5):634-644, November 1997 
'Novel lymphocyte-specific CC chemokines and their receptors" 



ZK 



Angel Zaballos, et al.. Biochem Biophys. Res. Comm., 227(3):846-853, October 1996. "Molecular 
Cloning and RNA Expression of Two New Human Chemokine Receptor-like Genes'* 



ZW 



Alfred Garzino-Pemo, et al.. Journal of Clinical Immunology , 18 (4):243-255, March 1998. 
"Chemokine Receptors and Chemokines in HIV Infection" 



ZZ 



George A. Donzella. et al.. Nature Medicine , 4 (1) 72-77, January 1998. 
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor" 



ZU 



Dominique Schols. etal. J. Exp. Med. , 186 (8): 1383-1388, October 1997. "Inhibition of T tropic 
HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4" 



Dominique Schols. et al. Jounral of Virology , 72 (5): 4032-4037, May 1998. 
T Cell Line Tropic Human Immunodeficiency Virus Type 1 that is Made Resistant to Stromal 
Cell-Derived Factor 1a Contains Mutations in the Envelope gp120 but does not show a switch in 
Coreceptor Use" 

Beatrice Labrosse, et al.. Journal of Virology , 72 (8): 6381-6388. August 1998. "Determinants for 
Sensitivity of Human Immunodeficiency Virus Coreceptor CXCR4 to the Bicyclam AMD3100" 



ZF 



ZZ 



oen smvity or numan immunoaenciency virus oorecepior UAur\4 iu ine piuyuiam mmuo iuu 
Christopher C. Broder and Ronald G. Collman, J. of Leukocycte Biology , 62: 20-29 July 1997 
Chemokine receptors and HIV" 



ZK 



Joanna F. Berson and Robert W. Poms, Immunology , 10: 237-248, 1998. 
"Structure function studies of the HIV-1 coreceptors" 



zr 



£)<AMINEF* 

'EXAMINER: Inrtia 
through citation if 
applicant. 



DATE CONSIDERED 




. .l/aWfl„. „ 

Her or not citation is in cOnformancewith MPEP 609; Praw line 



considered. Include copy of this form with next communication to